I'm so close to surgery without pain. Dr. Thomas Bolton is one of London's top surgeons, brilliant and fast, he is however constantly troubled by the amount of pain his patients go through, for this be a time before anaesthesia. Painstakingly working on a formula to put patients to sleep during surgery, Bolton is convinced he has found a breakthrough, but upon trialling it in front of the board it goes terribly wrong. He continues undaunted, but as he keeps testing the formula out on himself he becomes badly addicted, unable to get the hospital board to sanction his research, he gets involved with a dastardly group of murderers who kill and then sell off corpse's to a suspect doctor. Make no (saw) bones about it, this is a wonderful Boris Karloff performance, the amount of sympathy and earthy fortitude he puts into Dr. Bolton is very impressive. The plot isn't up to much and fans of staple horror requirements will hardly get any titillation from it, but as a crime picture and a character study it comes out smiling and delivers the goods. The sets are very good, check out the frontal entry into the Seven Dials area, and now with better digital transfers the picture's black and white texture ripens the watching experience. It's a film that I suppose is easily forgotten quickly after the viewing, but it's well worth watching for Karloff's turn and an ending that is strangely sad but uplifting at the same time. 6/10